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How a uniquely human genetic tweak changed the voices of mice : NPR

The Owner Press by The Owner Press
February 22, 2025
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A brand new examine exhibits that giving mice the human model of a gene modifications their squeak, suggesting a number of the genetic underpinnings of language.



ADRIAN FLORIDO, HOST:

Folks like to speak. We’re distinctive within the animal kingdom by way of how a lot we talk and the sorts of data we talk about. Scientists try to grasp how this particular trait advanced on the genetic stage. NPR’s Nell Greenfieldboyce stories on what occurred just lately when researchers gave mice the human model of 1 specific gene.

NELL GREENFIELDBOYCE, BYLINE: If somebody requested you what sort of sound a mouse makes, you’d most likely go, squeak. However mice additionally make some sounds within the ultrasonic vary that people cannot hear. Should you course of these sounds in order that we will hear them…

(SOUNDBITE OF HIGH-PITCHED MOUSE SQUEAKING)

GREENFIELDBOYCE: …It is quite a bit like hen track. Erich Jarvis is a researcher at Rockefeller College in New York. He says mouse pups chirp once they’re taken away from their moms, and as adults, male mice string lengthy sequences of those chirps collectively.

ERICH JARVIS: And so they’ll sing them to the females as a courtship habits.

GREENFIELDBOYCE: Just lately, Jarvis teamed up with another researchers at Rockefeller College to review one specific gene. This gene is present in dwelling creatures, from mammals to birds, however there’s one specific variant that is discovered solely in folks. After they put that uniquely human variant into mice, it subtly modified the vocalizations made by infants and grownup males.

(SOUNDBITE OF HIGH-PITCHED MOUSE SQUEAKING)

GREENFIELDBOYCE: Jarvis says their evaluation confirmed that the mouse songs turned extra advanced.

JARVIS: So the truth that we had a change within the vocal habits was actually thrilling.

GREENFIELDBOYCE: He says this gene could possibly be associated to speech and language, though it is clearly not the one language gene.

JARVIS: I do not assume that one gene goes to be accountable – poof – and you bought spoken language, proper?

GREENFIELDBOYCE: Nonetheless, this gene is particularly intriguing as a result of it is energetic within the mind and this variant appears to be solely present in trendy people. Robert Darnell is a neuroscientist, additionally at Rockefeller College. He says they’ve checked out genetic data in databases and located that this variant is current in nearly each single particular person from all over the world, however it’s not present in chimps or extinct human species like Neanderthals.

ROBERT DARNELL: This can be a human language gene that modified and switched early within the improvement of Homo sapiens.

GREENFIELDBOYCE: A report on the findings seems within the journal Nature Communications, and it is acquired the eye of different scientists within the genetic underpinnings of language. Cedric Boeckx is with the Catalan Institute for Superior Research and Analysis and the College of Barcelona. He says it is an actual advance.

CEDRIC BOECKX: It is one gene amongst many nonetheless to be uncovered in a fancy community that affect this and make potential this capability now we have.

GREENFIELDBOYCE: He cautions, although, that it is onerous to make a bounce from mouse vocalizations to human speech. A mouse just isn’t your typical vocal learner.

BOECKX: It produces vocalizations, however they’re principally innately constrained. So it isn’t like us.

GREENFIELDBOYCE: He says people are particular in how we talk, and figuring out the checklist of genes concerned in language may inform us one thing about how people got here to be who we’re.

Nell Greenfieldboyce, NPR Information.

(SOUNDBITE OF MUSIC)

Copyright © 2025 NPR. All rights reserved. Go to our web site terms of use and permissions pages at www.npr.org for additional data.

NPR transcripts are created on a rush deadline by an NPR contractor. This textual content might not be in its closing type and could also be up to date or revised sooner or later. Accuracy and availability might differ. The authoritative document of NPR’s programming is the audio document.



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