• The School of Business
  • The School of Arts
  • The School of Wellness
  • The School of Fitness
  • The School of Public Affairs
Saturday, October 18, 2025
  • Login
  • Register
No Result
View All Result
  • The School of Business
  • The School of Arts
  • The School of Wellness
  • The School of Fitness
  • The School of Public Affairs
No Result
View All Result
Press Powered by Creators

Stanford Scientists Successfully Reverse Autism Symptoms in Mice

The Owner Press by The Owner Press
September 2, 2025
in Business News
Reading Time: 3 mins read
A A
0
Share on FacebookShare on Twitter


Lab Mouse Petri Dish
Stanford Medication researchers have found that hyperactivity in a mind area referred to as the reticular thalamic nucleus could underlie behaviors related to autism spectrum dysfunction. By dampening exercise on this space utilizing experimental medication and neuromodulation methods, they had been capable of reverse autism-like signs in mice, from seizures to social deficits. Credit score: Shutterstock

Overactivity within the reticular thalamic nucleus was proven to trigger autism-like behaviors in mice. Medication that scale back this exercise reversed the signs.

Researchers at Stanford Medicine finding out the neurological foundation of autism spectrum disorder have found that excessive activity in a particular brain region may be responsible for driving behaviors commonly linked to the condition.

Using a mouse model of autism, the team identified the reticular thalamic nucleus, a structure that filters sensory information between the thalamus and cortex, as a promising treatment target.

Importantly, they showed that administering drugs to dampen activity in this brain region reversed autism-like symptoms in the mice, including seizure susceptibility, heightened sensitivity to stimuli, increased motor activity, repetitive actions, and reduced social interaction.

Shared pathways with epilepsy

These same drugs are also under investigation as potential treatments for epilepsy, underscoring how the mechanisms that drive autism spectrum disorders and epilepsy may intersect in the brain and help explain why the two conditions often appear in the same individuals.

The findings were recently published in Science Advances. The senior author of the study is John Huguenard, PhD, professor of neurology and neurological sciences. The lead author is Sung-Soo Jang, PhD, a postdoctoral scholar in neurology and neurological sciences.

Overactivity in the reticular thalamic nucleus

Connections between the thalamus and cortex have been linked to autism in both people and animal models, but the specific contribution of the reticular thalamic nucleus had remained uncertain.

In the new study, the researchers recorded the neural activity of this brain region in mice while observing the animals’ behavior. In mice that had been genetically modified to model autism (Cntnap2 knockout mice), the reticular thalamic nucleus showed elevated activity when the animals encountered stimuli like light or an air puff as well as during social interactions. The brain region also showed bursts of spontaneous activity, causing seizures.

Epilepsy is much more prevalent in people with autism than in the general population — 30% versus 1% — though the mechanisms are not well understood. Recognizing this connection, the researchers tested an experimental seizure drug, Z944, and found that it reversed behavioral deficits in the autism mouse model.

With a different experimental treatment that genetically modifies neurons to respond to designer drugs, known as DREADD-based neuromodulation, the researchers could suppress overactivity in the reticular thalamic nucleus and reverse behavioral deficits in the autism mouse model. They could even induce these behavioral deficits in normal mice by ramping up activity in the reticular thalamic nucleus.

The new findings highlight the reticular thalamic nucleus as a novel target for the treatment of autism spectrum disorders.

Reference: “Reticular thalamic hyperexcitability drives autism spectrum disorder behaviors in the Cntnap2 model of autism” by Sung-Soo Jang, Fuga Takahashi and John R. Huguenard, 20 August 2025, Science Advances.
DOI: 10.1126/sciadv.adw4682

Never miss a breakthrough: Join the SciTechDaily newsletter.



Source link

Tags: AutismMicereversescientistsStanfordSuccessfullySymptoms
Share30Tweet19
Previous Post

Italy hits back at French PM's "fiscal dumping" claim

Next Post

Why Sarah Drew’s Dr. April Kepner Left Grey’s Anatomy

Recommended For You

Donald Trump says Putin wants to ‘stop fighting’ in Ukraine ahead of European leaders’ emergency talks | World News
Business News

Donald Trump says Putin wants to ‘stop fighting’ in Ukraine ahead of European leaders’ emergency talks | World News

by The Owner Press
February 16, 2025
India’s Licence Raj offers America important lessons
Business News

India’s Licence Raj offers America important lessons

by The Owner Press
July 2, 2025
How Trump’s tariff turbulence will cause economic pain
Business News

How Trump’s tariff turbulence will cause economic pain

by The Owner Press
February 4, 2025
Poundland to stop paying rent at hundreds of stores in rescue deal | Money News
Business News

Poundland to stop paying rent at hundreds of stores in rescue deal | Money News

by The Owner Press
June 17, 2025
HealthEdge and UST HealthProof Merge to Modernize Health Plans
Business News

HealthEdge and UST HealthProof Merge to Modernize Health Plans

by The Owner Press
September 8, 2025
Next Post
Why Sarah Drew’s Dr. April Kepner Left Grey’s Anatomy

Why Sarah Drew's Dr. April Kepner Left Grey's Anatomy

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

LEARN FROM TOP VERIFIED OWNERS

Book an Office Hour

Related News

Digital Health Funding Q3 2025: Choppy Undercurrents Beneath a Steady Surface

Digital Health Funding Q3 2025: Choppy Undercurrents Beneath a Steady Surface

October 6, 2025
CSI Savannah State: $899k federal grant bolsters university's forensic science program – Savannah Morning News

Alabama A&M University names construction adviser for new science, student amenities buildings – Alabama NewsCenter

January 12, 2025
CSI Savannah State: $899k federal grant bolsters university's forensic science program – Savannah Morning News

California Science Center IMAX Theater presents the West Coast Premiere of "Superhuman Body 3D" Narrated by Academy Award® Winner Matthew McConaughey On March 29, 2025 – Morningstar

March 20, 2025

The Owner School

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    

Recent Posts

Joe Rogan Blasts Trump For Sending Troops Into U.S. Cities

Joe Rogan Blasts Trump For Sending Troops Into U.S. Cities

October 18, 2025
‘No Kings’ protest live updates: millions expected to gather across the US for anti-Trump protests | Trump administration

‘No Kings’ protest live updates: millions expected to gather across the US for anti-Trump protests | Trump administration

October 18, 2025
Andre Leon Talley: Style Is Forever Exhibition Honors the Late Fashion Icon at SCAD FASH

Andre Leon Talley: Style Is Forever Exhibition Honors the Late Fashion Icon at SCAD FASH

October 18, 2025

CATEGORIES

  • Business News
  • The School of Arts
  • The School of Business
  • The School of Fitness
  • The School of Public Affairs
  • The School of Wellness

BROWSE BY TAG

Australia big Cancer China climate Day deal Donald Entertainment Football Gaza government Health League live Money News NPR people Politics reveals Science scientists Season Set show Star Starmer Study talks tariff tariffs Tech Time Top trade Trump Trumps U.S Ukraine War White win World years

RECENT POSTS

  • Joe Rogan Blasts Trump For Sending Troops Into U.S. Cities
  • ‘No Kings’ protest live updates: millions expected to gather across the US for anti-Trump protests | Trump administration
  • Andre Leon Talley: Style Is Forever Exhibition Honors the Late Fashion Icon at SCAD FASH
  • The School of Business
  • The School of Arts
  • The School of Wellness
  • The School of Fitness
  • The School of Public Affairs

© 2024 The Owner Press | All Rights Reserved

Welcome Back!

Login to your account below

Forgotten Password? Sign Up

Create New Account!

Fill the forms bellow to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • The School of Business
  • The School of Arts
  • The School of Wellness
  • The School of Fitness
  • The School of Public Affairs
  • Login
  • Sign Up

© 2024 The Owner Press | All Rights Reserved